Key takeaways

  • Supporting a loved one with transthyretin amyloidosis (ATTR-CM) to remain active involves encouraging familiar routines, managing energy levels, and fostering social connections to enhance their quality of life.
  • It’s important to help individuals with ATTR-CM stay physically active within their capabilities, adapting exercises to their condition and listening to their body’s signals.
  • Empowering those with ATTR-CM to make their own decisions about daily activities, healthcare, and future plans is key to maintaining their independence and dignity.

Transthyretin amyloidosis (ATTR-CM) is a serious, progressive heart condition in which the protein transthyretin (TTR) builds up in the heart muscle. Over time, these protein deposits can stiffen the heart and make it harder to pump blood effectively throughout the body.

ATTR-CM is often misdiagnosed or undiagnosed. Hereditary ATTR-CM can cause symptoms earlier in adulthood in some people, though symptoms most often appear later in life. Wild-type ATTR-CM is commonly seen in adults ages 75 and older.

In recent years, treatment options for ATTR-CM have expanded, with advances that may help manage symptoms, support quality of life, and slow disease progression.

People living with ATTR-CM may experience symptoms that affect everyday life, including:

  • shortness of breath while at rest or with minimal activity
  • fast or irregular heart rate
  • heart palpitations
  • swelling in the lower legs, ankles, or feet
  • chest congestion, coughing, or wheezing
  • difficulty thinking or confusion
  • abdominal bloating

If you or your loved one has been diagnosed with ATTR-CM, staying engaged in daily activities is crucial, even when symptoms make things more challenging. With the right support, there are ways to help maintain independence and support quality of life.