Rexulti (brexpiprazole) is a medication used to treat conditions like major depressive disorder (MDD), schizophrenia, and agitation associated with Alzheimer’s disease.

Many Medicare Part D and Medicare Advantage prescription drug plans cover this medication. Medicare has a search tool that lets you know if the Medicare drug plan you’re considering covers Rexulti (brexpiprazole).

In 2025, Medicare has an out-of-pocket maximum of $2,000. That means $2,000 is the maximum amount you’ll pay for prescription medications in 2025. Once you have spent that amount, your covered prescriptions are $0.

The price of Rexulti (brexpiprazole) through your Medicare Part D or Medicare Advantage drug plans will depend on several things, like:

  • your zip code
  • the prescription drug plan you choose
  • the pharmacy you use
  • your plan’s deductible

Some Medicare Advantage plans may still have a copay for prescriptions. This may lower your monthly costs until you meet the $2,000 annual maximum or if you don’t spend $2,000 a year on prescription medication.

There’s no generic form of Rexulti available for purchase.

Yes, there are several ways to save on prescription medication costs. If you’re enrolled in Medicare and have a lower income, you may qualify for the Extra Help program. In 2025, individuals on Extra Help plans may pay $4.90 for generic medications and $12.15 for brand-name medications.

Starting January 1, 2025, Medicare will offer a monthly payment system called the Medicare Prescription Payment Plan. This is to help you spread out the cost of your prescription medications over several months. When you search for your Part D plan, you can see what you’d pay each month using this system.

There are other ways to get help with prescription drug costs, such as State Pharmaceutical Assistance Programs.

Medicare Part D and Medicare Advantage drug plans cover most medications. Before choosing a drug plan, you can search for your medications to be sure any plan you choose covers them. There are also other state, pharmaceutical company, and Medicare programs that may help you save on your prescription drug costs.