Rexulti (brexpiprazole) is a prescription drug that works to treat depression, schizophrenia, and other mental health conditions by changing certain brain chemicals that regulate mood. Your response to this drug may vary based on your medical history and diagnosis.

Rexulti is prescribed to treat the following:

Rexulti contains the active drug brexpiprazole. It belongs to a class of drugs called atypical antipsychotics.

Rexulti’s exact mechanism of action (MOA) isn’t known. It’s thought that it works by regulating the levels of two neurotransmitters — dopamine and serotonin — which are chemicals in your brain that regulate mood. These chemicals are thought to be irregular in people with the conditions Rexulti is approved to treat.

It may take a few days to several weeks for Rexulti to start reducing your symptoms. How quickly the drug works depends on individual factors, such as your condition and how your body responds to treatment.

For more information on what to expect with Rexulti treatment, talk with your doctor or pharmacist.

Medical Perspective

When Rexulti is working in your body, you’ll notice an improvement in your overall mood and behavior. After a few weeks of taking Rexulti, your doctor will likely ask you questions about your symptoms and how you’re feeling. Depending on your condition, you’re likely to experience the following: reduced sadness, better concentration, less agitation and irritability, and an increased desire to be around others.

If your symptoms are not getting better after several weeks of taking the medication, your doctor will likely recommend switching to another medication.

— Kristina D. Carter, PharmD, MBA, MHA

Quotes represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.